Stop me from pulling my hair out!
I was using a USB 2 3-port hub on a MS Surface with a wireless mouse dongle and a 3.0 thumb drive plugged in. I just purchased an Anker 4-port Ultra Slim USB 3.0 Data Hub and if I have the wireless mouse alone plugged in everything is fine. If I plug in the thumb drive additionally and go to access the the mouse the mouse freezes freezes. When the thumb drive is idle the mouse works.